Paget's disease of the bone and its management.

Paget’s disease of bone (PD) is a monostotic or polyostotic non-hormonal osteometabolic disorder. Over a century after the original disease was described by Sir John Paget in 1877, and despite recent intensive studies and widespread interest, its aetiology remains obscure. This review describes the pathomechanism of the structural changes which occur in bone affected with PD, induced by the different dynamic patterns of activity of the disease, and outlines the current methods of treatment.